Endocrine Abstracts

Background: Thyroid carcinoma represents the most frequent form of cancer of the endocrine glands. In Italy, temporal trend shows a significant increase of incidence rates. Papillary thyroid cancer is the most common thyroid malignancy. Papillary thyroid carcinoma happens to be a multicentric tumor and trends to spread to the lymph nodes in the early stage of the disease. Thus early diagnosis is vital to improve the outcome for patients with thyroid cancer. The aim of this stu...

Background: To evaluate the technical feasibility, effectiveness, and safety of transoral robotic thyroidectomy (TORT), using the da Vinci system through analysis of our series of 1000 consecutive patients.Method: A review of a prospectively designed database at our institute from September 2012 to February 2022 revealed a series of 1000 consecutive TORT patients with preoperative diagnosis of various thyroid diseases. Clinicopathologic characteristics a...

Background: Papillary thyroid cancer is a well-differentiated neoplasm and is the most common, accounting for 65–85% of all thyroid cancer. On the other hand, medullary carcinoma represents only 3–12%. The concurrence of distinct medullary and papillary carcinoma within the same thyroid has been sporadically described.Case presentation: We report a rare case of simultaneous sporadic both multicentric medullary and papillary thyroid cancer with ...

Background: Amyloidosis is an important etiological factor of end stage renal disease. Apart from major target organs as cardiovascular, respiratory and gastrointestinal system, endocrine organs can also be involved. Amyloid goitre was described for the first time by Beckmann in 1858. Approximately 200 cases of amyloid goiter have been reported in English literature.Case presentation: The patient is a 67-year-old woman. The patient referred in 1989 the p...

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor arising from parafollicular C-cells. Nowadays different targeted therapies are available, directed mostly against the main genetic driver of MTC, RET, and against the common pro-oncogenic pathways of VEGF, EGFR and c-MYC. Despite this, an escape phenomenon has been observed with sudden disease progression during treatment, leaving surgery as the only curative treatment. The evaluation of pre and post treatment ge...

Background: Cytology is the gold standard method for the differential diagnosis of thyroid nodules, though 25−30% of them are classified as indeterminate and, in some cases, surgery is required for a definitive diagnosis. Aim: In order to reduce unnecessary thyroid surgeries, we set up a ‘thyroid risk score’ (TRS) to increase the diagnostic accuracy in a large series of patients with indeterminate cytology and to apply it to a validation ...

Introduction: Transoral Robotic Thyroidectomy (TORT) is progressively gaining its ground in robotic thyroid surgery. With accumulated techniques and developments, TORT can also be applied for completion thyroidectomy. We review our experience with the transoral robotic approach to completion thyroidectomy to evaluate the safety and surgical feasibility.Methods: Consecutive patients receiving completion TORT operation were evaluated from a prospective dat...

Background: The incidence of thyroid cancer in South Korea has increased rapidly. Increase in medical surveillance and access to health care services have enhanced the detection of asymptomatic tumors. We investigated the differences of tumor characteristics between South Korean patients and Northern Italian patients subject to different healthcare systems.Methods: The demographic, histopathologic and management features of thyroid cancer operated in two...

Obesity has become one of the greatest public health concerns and is known to be a major risk factor for cardiac, respiratory and metabolic diseases. Bariatric surgery is the most effective treatment for morbid obesity. According with guidelines, surgery is indicated for treatment of patients with BMI greater than 40 kg/m2 or above 35 kg/m2, with at least one obesity-related comorbid condition, such as as type 2 diabetes, hypertension, dyslipidemia, sleep...

Bariatric surgery is the most-effective treatment for morbid obesity, superior to medical treatment. Metabolic syndrome (MS) is a condition characterized by multiple major risk factors for coronary heart disease, diabetes, fatty liver, and several cancers; the main, diagnostic, components of MS are low HDL-cholesterol (<40 mg/dl in man, <50 mg/dl in woman), raised triglycerides (>150 mg/dl), blood pressure >130/85 mmHg, fasting plasma glucose >100 mg/dl and...